Description
Dapoxetine hydrochloride powder video anesthesia
Raw Dapoxetine Hydrochloride Anesthesia Powder basic Characters
Dapoxetine is an organic compound of the selective serotonin reuptake inhibitor class but with no antidepressant effect. The drug is specifically developed to treat premature ejaculation in adult males between the ages of 18 and 64 who meet all of the following criteria:
1. Continuous or repeated ejaculation of the penis before, during or shortly after insertion into the vagina and only before the lack of sexual satisfaction,
2. Significant personal distress or interpersonal barriers due to premature ejaculation (PE),
3. Poor ability to control ejaculation.
Chemical properties of Dapoxetine
The dapoxetine hydrochloride tablet is a gray film-coated tablet, which is white or off-white after removing the coating.
Main ingredient: Dapoxetine hydrochloride.
IUPAC Name: (1S) -N, N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine
Chemical structure of Dapoxetine HCL powder
1. 2D structure:
2. 3D Conformer:
Molecular formula: C21H23NO
Molecular weight: 305.421 g / mol
C.
Simple description of Dapoxetine
At present, there is no specific regulation for the treatment of male premature ejaculation with dapoxetine hydrochloride tablets. There is no specific regulation for how long the drug is used for treatment.It depends on the severity of the symptoms of premature ejaculation. The difficulty of the treatment is different. The time of medicine cannot be generalized. However, the drug can improve the symptoms of premature ejaculation, so that patients can take medications based on their symptoms.
Dapoxetine is primarily intended for the treatment of 18 in 64 male premature ejaculation (XE) patients who meet all of the following conditions, including:
1. The penis is minimally small before, during or shortly after insertion into the vagina and before sexual satisfaction. Sexual stimuli are continuous or repeated ejaculation,
2. Significant personal distress or interpersonal barriers due to premature ejaculation (PE),
3. Poor control of ejaculation.
Dapoxetine has already been approved as a drug in Europe and the United States as having a high effect on the treatment of premature ejaculation. When you take dapoxetine, serotonin, a substance in the brain, is secreted. This serotonin is a substance that burns the excitement of the brain or causes a relaxing effect. Tension and arousal are resolved, the effect of adrenaline is also reduced, so that ejaculation times can be delayed.
Dapoxetine hydrochloride can effectively inhibit 5-HT reuptake and increase 5-HT concentration in the synaptic cleft by inhibiting the 5-HT transporter. Studies have shown that dapoxetine centrally inhibits the ejaculation reflex, and the lateral nucleus of giant cells is an essential brain structure. When the dapoxetine concentration is high, the monoamine protein transport system can be inhibited and dopamine reuptake is also inhibited. Dapoxetine increases the latency of the pudendal motor neuron reflexes and improves sexual function.
How long it takes for dapoxetine hydrochloride tablets to be effective is not generalized. Treatment depends on the severity of the symptoms of premature ejaculation. The difficulty of treatment is different and the time of taking the medicine is different.
Dapoxetine mechanism of action
The mechanism of action of dapoxetine in the treatment of premature ejaculation may be related to the inhibition of the reabsorption of serotonin by neurons, thus affecting the potential difference of neurotransmitters acting on receptors before and after cellular synapses.
Dapoxetine is effective for premature ejaculation because it has the effect of increasing the concentration of serotonin which suppresses arousal in the brain.
Serotonin is usually reabsorbed by the synapse, but taking dapoxetine inhibits the reabsorption and suppresses serotonin.
Serotonin suppresses dopamine which amplifies the pleasure, anxiety and adrenaline that comes out when you are nervous, so it is possible to lengthen the time to ejaculate.Dapoxetine is effective for premature ejaculation because it has the effect of increasing the concentration of serotonin which suppresses arousal in the brain.
Serotonin is usually reabsorbed by the synapse, but taking dapoxetine inhibits the reabsorption and suppresses serotonin.
Serotonin suppresses dopamine which amplifies the pleasure, anxiety and adrenaline that comes out when you are nervous, so you can extend the time to ejaculate.
Human ejaculation is mainly mediated by the sympathetic nervous system. The reflex pathway of ejaculation is derived from the spinal reflex center, which is mediated by the brain stem, which is initially affected by many brain nuclei (median preoptic nucleus and hypoventricular paraventricular nucleus).
Dapoxetine HCL Pharmacokinetics
After oral administration, dapoxetine is rapidly absorbed and reaches a maximum plasma concentration (Cmax) after approximately 1-2 hours. Absolute bioavailability is 42% (range 15-176%). After a single oral administration of 30 mg and 60 mg dapoxetine in the fasted state, peak plasma concentrations (297 ng / ml and 498 ng / ml, respectively) were reached after 1.01 and 1.27 hours, respectively. Ingestion of a high-fat diet may moderately reduce the dapoxetine Cmax (10%) and moderately increase the AUC (12%), while also slightly delaying the maximum dapoxetine concentration, however, a high-fat diet does not affect the extent of absorption. None of these changes are of clinical significance. Bentley can be served with or without meals.
After administration to the human body by intravenous injection, the estimated initial, mean and terminal half-lives of dapoxetine are 0.10, 2.19 and 19.3 hours, respectively.
The metabolites of excreted dapoxetine are mainly eliminated from the urine in the conjugated situation. No active substance was detected in the urine. Dapoxetine is rapidly cleared and evidence is background of blood concentration 24 hours after administration (less than 5% of maximum concentration). The daily dose of dapoxetine is very small. The terminal half-life of oral administration is approximately 19 hours. The half-life of desmethyl dapoxetine is similar to that of dapoxetine.
Use of Dapoxetine
Treatment of male patients with premature ejaculation (PE)
Dapoxetine hydrochloride tablets can effectively improve ejaculation control ability, significantly improve sexual life satisfaction, effectively prolong ejaculation latency.
While using medication, patients can also use some small measures to improve premature ejaculation symptoms, regulate mood, strengthen communication between husband and wife, rational diet, strengthen exercise, run every day and participate in a physical activity every week. It is also a good choice for playing football and basketball to improve physical fitness and relieve psychological stress.
Dapoxetine dosage
The dosage of dapoxetine hydrochloride tablets is oral and the tablets should be swallowed intact, patients are advised to take at least a full glass of water for medication, patients should try to avoid injury caused by prodromal symptoms such as syncope or dizziness.
The recommended amount of dapoxetine hydrochloride tablets for all patients in adult males (18 to 64 years of age) is 30 mg and should be taken 1 to 3 hours before sexual life. If the effect is not satisfactory after taking 30mg and the side effects are still within the acceptable range, the dosage can be increased to 60mg of the maximum recommended dose.
The maximum recommended dose is used every 24 hours.
The elderly (age 65 and over) This product has not been evaluated in the age of 65 and the safety and efficacy in patients above the crowd used, the main reason why the data on this product for use in this population is extremely limited in patients with mild renal impairment or Patients with renal impairment do not need to adjust their dose when taking this product, but should take it with caution. This product is not recommended for patients with severe kidney damage.
Indications Dapoxetine:
This product is intended for the treatment of male patients with premature ejaculation (PE) between the ages of 18 and 64 who meet all of the following conditions: the penis continues until it is inserted into the vagina, during or shortly after insertion and first sexual gratification is achieved, only due to minimal irritation. Or repeated ejaculation, and significant personal distress or interpersonal barriers due to premature ejaculation (PE), and poor ejaculation control.
(1) Adult males (18 to 64 years)
He recommends a first dose of 30 mg for all patients and should take approximately 1 to 3 hours before sexual intercourse. If the effect is not satisfactory after taking 30mg and the side effects are still within the acceptable range, the dosage can be increased to 60mg of the maximum recommended dose. The maximum recommended dose is used every 24 hours. This product can be taken before or after a meal.
If the physician chooses this product for the treatment of premature ejaculation, he should evaluate the risk and benefit reported by the patient for the first 4 weeks after using the drug, or evaluate the patient's risk-benefit ratio after using the dose. treatment 6 times and decide whether to continue using the product.
(2) The elderly (65 years and older)
Research has not yet evaluated the safety and efficacy of this product in patients aged 65 and over. The main reason for this is that the data on the use of this product in this population are extremely limited.
(3) Children and young people
This product is not intended for use by persons under the age of 18.
One tablet at a time can be taken indefinitely. The drug should be taken on an empty stomach.It is best to drink the tea before use long before this medicine is better to do a complete inspection system, depending on their disease in a doctor or pharmacist said and the organized safety for the drug in order to avoid misuse of the drugs, but do not arbitrarily increase the frequency of drug use during It is necessary to follow the doctor's instructions and embarrassment.
Overdose of dapoxetine
In general, symptoms of overdose of a selective serotonin reuptake inhibitor include serotonin-mediated adverse effects such as lethargy, gastrointestinal dysfunction such as nausea and vomiting, excitement, tremor, dizziness and tachycardia. In the event of an overdose, standard supportive measures should be taken as needed. There are currently no specific antidotes for this product.
Precautions from Hap Dapoxetine
1. General Precautions. Dapoxetine is only used for male patients with premature ejaculation. The safety of Dapoxetine in men who do not have premature ejaculation is unclear. At the same time, there are no data on the effect of Dapoxetine in delaying ejaculation in this population. It is recommended that patients do not take Beverly and “entertainment drugs” at the same time because the effect is unknown and serious adverse events can occur.
2. Patients are advised not to take stimulant psychotropic drugs while taking them.
3. Avoid alcohol intake while taking Dapoxetine.
4. Use Dapoxetine can cause syncope or dizziness
5. Also take moderate cytochrome P450 3A4 inhibitors such as erythromycin, clarithromycin, fluconazole, verapamil and diltiazem.
6.Taking a strong inhibitor of cytochrome P450 2D6 or a known cytochrome P450 2D6 Patients with weak metabolism should exercise caution in increasing the dose to 60 mg, as this may lead to increased exposure, which can lead to adverse reactions and severity higher dose-dependent.
7. Beneficial should not be used for mania / Patients with a history of hypomanic or bipolar disorder, at the same time, any patient with symptoms of the aforementioned disease should be discontinued on Dapoxetine.
8. Since the selective serotonin reuptake inhibitor may lower the epilepsy threshold value, any patient with seizures should be discontinued and patients with unstable epilepsy should avoid the use of Dapoxetine.
9. Dapoxetine should not be used in people under the age of 18.
10. Not recommended For patients with severe renal impairment, patients with mild or moderate renal impairment should be used with caution. Like other selective serotonin reuptake inhibitors, the use of Dapoxetine is associated with some ocular reactions. For example, pupil dilation and eye pain. Patients with elevated intraocular pressure or risk of narrow-angle glaucoma should be used with caution.
Dapoxetine HCL powder prohibited
1. Dapoxetine is prohibited for patients who are known to be allergic to dapoxetine hydrochloride or other excipients.
2. Dapoxetine is prohibited in patients with obvious pathological conditions in the heart [eg. Heart failure (NYHA II-IV), absence of abnormal conduction with permanent pacemaker therapy (grade 2 or 3 atrioventricular block or sick sinus syndrome), significant myocardial ischaemia and valvular disease]
3. Dapoxetine nor with monoamine oxidase inhibitors (MAOI)) Must not be used together within 14 days after discontinuing treatment with monoamine oxidase inhibitors.Likewise, monoamine oxidase inhibitors should not be used within 7 days of stopping Bili (see drug interactions).
4. Dapoxetine cannot be used with thioridazine or after discontinuing thiodazine treatment. Used in a few days. Similarly, thioridazine should not be taken within 7 days after stopping Dapoxetine (see section on drug interactions).
5. Dapoxetine is prohibited from taking ketoconazole, itraconazole, ritonavir, saquin Patients with strong inhibitors of cytochrome P450 3A4 such as vessel, telithromycin, nefazodone, naffenavir and atazanavir.
6. Dapoxetine is prohibited in patients with moderate and severe hepatic impairment.
Dapoxetine HCL powder Conclusion
When using dapoxetine hydrochloride tablets, it should be administered under the guidance of a doctor, who can improve the symptoms of the disease and at the same time better serve the drug.
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