Urolithin B


Urolithin B is also a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by the metabolism of polyphenols present in some nuts and fruits, in particular pomegranates. Urolithin B has been shown to cross the blood brain barrier and may have neuroprotective effects against Alzheimer's disease.



Urolithin B Basic features

product name Urolithin B CAS number 1139-83-9 Molecular formula C13H8O3 Weight Formula 212.2 Synonyms Urolithin B,


3-hydroxy-6H-benzo [c] chromen-6-one,

3-hydroxybenzo [c] chromen-6-one,


Form White in the light Storage and management Dry, dark and 0-4 C for short term or -20 C for long term.


, Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 November 2009). 'Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, show potent antioxidant activity in a cell assay.' J Agric Food Chem. 57 (21): 10181-6. doi: 10.1021 / jf9025794. PMID 19824638.

, Cerdá, Begoña, Tomás-Barberán, Francisco A., Espín, Juan Carlos (2005). 'Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts and oak-aged wine in humans: identification of biomarkers and individual variability'. Journal of Agricultural and Food Chemistry. 53 (2): 227-235. doi: 10.1021 / jf049144d. PMID 15656654.

, Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1, 55: 50-57.

, Rodriguez J, et al. Urolithin B, a recently identified skeletal muscle mass regulator. J Cachexia Sarcopenia Muscle. 2017 Aug, 8 (4): 583-597.

, Rombold JR, Barnes JN, Critchley L, Coyle EF. Consumption of ellagitannin improves strength recovery 2-3 days after eccentric exercise. Med Sci Sports Exerc 2010, 42: 493–498.

, Adams LS, Zhang Y, Seeram NP, Heber D, Chen S.Compounds derived from pomegranate ellagitannin exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila) 2010, 3: 108–113.


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