Description
Lorcaserin (1431697-94-7) video
Lorcaserin crude (1431697-94-7) HCL powder Basic characters
What is Lorcaserin
Lorcaserin (CAS 1431697-94-7), marketed under the brand name BELVIQ, the main ingredient is Lorcaserin HCL 846589-98-8 powder. FDA-approved lorcaserin HCL for people who are obese (with a body mass index, or BMI, of 30 or higher) or who are overweight (with a BMI of 27 or higher) and have at least one weight-related health condition such as type 2 diabetes, high blood pressure or high cholesterol.
What is Lorcaserin used for
Lorcaserin HCL 846589-98-8 powder is in a class of drugs known as serotonin receptor agonists. Lorcaserin HCL is used together with diet and bodybuilding to treat obesity, for fat loss. It is sometimes given to treat obesity associated with high cholesterol, high blood pressure, or type 2 diabetes. But Lorcaserin hydrochloride (Lorcaserin HCL) will not treat any underlying health conditions (such as heart disease, diabetes, hypertension).
Lorcaserin mechanism of action
Lorcaserin Hydrochloride Powder works by controlling appetite, specifically by activating the brain's receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Food intake is controlled by the satiety center, located in the ventromedial nucleus of the hypothalamus and in the hunger center in the lateral hypothalamus.Various inputs from the higher centers and gastrointestinal tracts converge in the arcuate nucleus, where there are two types of neurons that control food intake. First, food intake stimulatory group that produces agouti-related Y proteins and neuropeptides, and second, food intake inhibitory group containing cocaine and amphetamine regulated transcription (CART) and pro-opiomelanocortin neurons ( POMC). POMC contains 5C 2-HT receptors, which when activated releases alpha-melanocyte stimulating hormone (alpha-MSH). Both inhibitory and stimulatory neurons further project the paraventricular nucleus into the hypothalamus. The pelaventricular nucleus contains the appetite-inhibiting 4-dose melanocyte receptors (MC4Rs) lorcaserin acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes the release of MSH alpha. Further MSH alpha acts on MC4R in the paraventricular nucleus of the hypothalamus, leading to decreased appetite. In supratherapeutic doses, lorcaserin also acts on 5-HT 2B and 5-HT 2A receptors.
How to use Lorcaserin HCL powder (CAS 1431697-94-7)
Lorcaserin HCL powder is a white to off-white powder with a water solubility greater than 400 mg / mL. Each BELVIQ XR tablet contains 20.8 mg crystalline lorcaserin hydrochloride hemihydrate, equivalent to 20.0 mg lorcaserin hydrochloride powder, and the following inactive ingredients: microcrystalline cellulose NF, mannitol USP, hypromellose 2208 USP, ethylcellulose dispersion Type B NF 2910, hypromellose , colloidal silicon dioxide NF, polyvinyl alcohol USP, polyethylene glycol NF, titanium dioxide USP, talc USP, FD&C yellow # 6 / sunset yellow FCF, aluminum lake, iron oxide yellow NF, iron oxide red NF, and magnesium stearate NF.
Lorcaserin HCL 846589-98-8 powder is available as tablets and is typically taken 1-2 times a day, with or without food.Lorcaserin should be used alongside a reduced calorie diet and exercise plan.
Lorcaserin interactions
– monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), rasagiline (Azilect)
– selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil), fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox)
– tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil) and clomipramine (Anafranil)
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