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J 147 powder
J 147 (1146963-51-0) Dosage of use
Using an Alzheimer's disease (AD) drug discovery scheme based on multiple pathologies of old age, we identified a potent compound with efficacy in rodent memory and animal models of AD. Since this compound, J-147 powder, is a phenylhydrazide, it was feared that it could be metabolized into potentially carcinogenic aromatic amines / hydrazines. To explore this possibility, we examined the metabolites of J 147 powder in human and mouse microsomes and in mouse plasma. It is shown that J-147 powder (1146963-51-0) is not metabolised to aromatic amines or hydrazines, that the scaffold is exceptionally stable, and that the oxidative metabolites are also neuroprotective. It was concluded that the major metabolites of J 147 powder (1146963-51-0) may contribute to its biological activity in animals.
J 147, derived from curcumin, a component of the curry spice, has low toxicity and actually reverses the damage in neurons associated with Alzheimer's.
J 147 (1146963-51-0) was the mitochondrial protein known as ATP synthase, specifically ATP5A, a subunit of that protein. ATP synthase is involved in the mitochondrial generation of ATP, which cells use for energy.
The researchers showed that by reducing the activity of ATP synthase, they were able to protect neuronal cells from a range of toxicities associated with brain aging. One reason for this neuroprotective effect is the role of excitotoxicity in neuronal cell damage.
Excitotoxicity is the pathological process by which neurons are damaged and killed by excessive activation of the excitatory neurotransmitter glutamate receptors. Think of it as a bit like a light switch on and off so quickly that it ends up blowing up the light bulb.
Recently, the role of ATP synthase inhibition for neuroprotection against excitotoxic damage was demonstrated in a mouse study . The second study showed that mouse models expressing the human form of the mutant ATPase inhibitory factor 1 (hIF1), which causes prolonged inhibition of ATP synthase, were more resistant to neuronal death after excitotoxic damage. These data are consistent with this new J 147 powder study, in which an increase in IF1 in mice reduced ATP synthase activity (specifically ATP5A) and was neuroprotective.
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The data presented here demonstrate that J-147 powder has the ability to salvage cognitive deficits when administered in an advanced stage of the disease. The ability of J-147 powder to improve memory in aged AD mice correlates with its induction of neurotrophic factors NGF (nerve growth factor) and BDNF (brain derived neurotrophic factor) and several BDNF responsive proteins which are important for learning and memory.Comparison of J-147 powder (1146963-51-0) and donepezil in the scopolamine model showed that while both compounds were comparable to short-term memory rescue, J-147 powder was superior to spatial memory rescue. and a combination of the two worked best for contextual memory and memory.
Alzheimer's disease is a progressive brain disease, recently ranked as the third leading cause of death in the United States, affecting more than five million Americans. It is also the most common cause of dementia in the elderly, according to the National Institutes of Health. While most drugs developed in the last 20 years target amyloid plaque deposits in the brain (which are a hallmark of the disease), few have proven effective in the clinic.
'While most of the drugs developed in the last 20 years target amyloid plaque deposits in the brain (which are a hallmark of the disease), none have proven effective in the clinic,' says Schubert, senior author of the study.
Several years ago, Schubert and his colleagues began to approach the treatment of the disease from a new perspective. Instead of targeting amyloid, the lab decided to zero out the main risk factor for old age. Using cell screens against age-associated brain toxicities, they synthesized J 147 (1146963-51-0) powder.
Previously, the team found that J-147 powder could prevent and even reverse memory loss and Alzheimer's disease in mice that have an inherited version of the Alzheimer's, the most commonly used mouse model. However, this form of the disease comprises only about 1% of Alzheimer's cases. For everyone else, old age is the main risk factor, says Schubert.The team wanted to explore the drug candidate's effects on a rapidly aging breed of mice and experience a version of dementia that more closely resembles human age-related ailment.
J 147 Raw Powder
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