♣ NAD + is an essential coenzyme necessary for life and cell functions.
♣ Levels of NAD +, especially its NAD + form, naturally decrease with age in many tissues.
♣ The body creates NMN as an intermediate step or 'precursor' of NAD +. Put simply: higher NMN levels mean higher NAD + levels.
Noted: In the following articles, NMN used instead of β-nicotinamide mononucleotide (NMN)
Nicotinamide Mononucleotide: Benefits and Uses
Aging is a natural process that can put a strain on your physical, mental and aesthetic health. The first signs of aging manifest themselves on the face and neck region in the form of fine lines and wrinkles. The cosmetic effects of aging are often further exaggerated by exogenous factors such as UV exposure resulting in photodamage of the skin along with stress, anxiety and environmental pollutants that clog pores resulting in chronic irritation and acne.
These wrinkles are only the aesthetic and outward sign of aging, but internally they can affect your ability to carry out the activities of daily life with the same enthusiasm and energy as before.Additionally, aging can affect weight and metabolism, often causing unhealthy weight gain associated with slow basal metabolic rate.
The changes associated with aging cannot be avoided for the most part because some of them are the result of reduced mitochondrial metabolism and changes in gene expression. Most of the physiological changes that occur with aging are the result of decreased levels of NAD +, an important coenzyme for homeostasis and metabolism found in all living organisms.
During our youth, this coenzyme participates in almost all mitochondrial reactions that produce energy and is abundantly present in the body. However, as we age, NAD + levels begin to decline significantly.
Anti-aging supplements are widely promoted and used by people around the world in hopes of counteracting the effects of aging. However, not all of them are effective as most of them do not affect the levels of NAD + in the body. As a result of several studies. scientists and researchers have found a solution to combat the signs of aging, an elixir of life, namely the Nicotinamide Mononucleotide which immediately after oral consumption converts into NAD + in the body.
What is Nicotinamide Mononucleotide (NMN)?
Nicotinamide Mononucleotide is a nucleotide derived from niacin or vitamin B3 which can also be found, as it is, in some fruits and vegetables such as avocado and edamame. NMN has recently gained ground as a potential anti-aging supplement, mainly following the publication of the book Lifespan, by David Sinclair.
NAD + has long been known to be the hallmark of aging, but fighting the effect of aging on its levels has been difficult.This is mainly due to the fact that initial studies focused on increasing NAD + levels in the body by using NAD + supplements. However, it was soon discovered that NAD + has poor bioavailability in the body, which means that it is not easily absorbed and that its exogenous consumption has no effect on its endogenous levels.
The NMN supplement is a potent precursor of NAD + which is crucial in the energy production process in the human body. However, the first research on the use of NMN powder or supplement as a potential anti-aging supplement was only conducted in the year 2020. NMN still has a long way to go in the research world, but the studies conducted so far have demonstrated that benefits and hypothesized effects of NMN on aging.
Levels of NAD + can be increased by one of its two important precursors, NMN as mentioned above or NR. NMN and NR go together, with the conversion of NMN to NR being crucial for the absorption of the former in the body. NR stands for Nicotinamide riboside which can significantly increase endogenous levels of NAD +. NR supplementation to combat the effects of aging has been thoroughly researched and NR supplements have been declared 'safe and tolerable' supplements.
How does NMN work on the body?
NMN plays a vital role in the energy production process and DNA repair in the body, albeit indirectly. NMN promotes the synthesis or production of NAD + in the body to overcome its deficiency, via the lifeline. NAD + can be synthesized in more than one way, and the way out depends on proper functioning of NMN. Rescue pathway refers to a pathway that produces NAD + with the end products of NAD + breakdown such as niacinamide or NAM. NAM converts directly to NMN which then, through various steps, produces NAD +.This is the most important function of NMN in the body and is the main reason behind the growing popularity of NMN supplements.
Once NMN supplements are taken orally, they are believed to be converted into NR in the body because the NMN compound is unable to pass through membranes, into cells. After NR has entered the cell, it is then converted back into NMN via the effects of a specific enzyme, nicotinamide ribose kinase or NRK. This NMN then undergoes the rescue path for the biosynthesis of NAD + to replenish the levels of the latter in the human body.
It is important to note here that replenishment of NAD + through NMN supplementation not only results in increased energy but also has many other health benefits that only increase the attractiveness of NMN supplementation.
Health Benefits of NMN
The anti-aging properties of NMN are not only the result of an increase in NAD + levels, but also the pathways and functions of NMN in the human body. The main benefit of NMN is still its ability to increase cellular and physical energy as it is a NAD + booster, however, other benefits should not be overlooked especially if you are looking into whether NMN supplementation is the right choice for you. you.
Being a NAD + booster allows NMN to produce many other health benefits, such as:
· Management of obesity
The incidence of obesity has increased significantly from 30 years ago, with the percentage of childhood obesity nearly doubling in those 30 years. This is of particular concern because obesity predisposes you to several other comorbidities that can be fatal. A low basal metabolic rate is the main reason behind the age-related obesity often seen in elderly individuals.Controlling this specific type of obesity requires a multifactorial approach that targets hunger hormones along with metabolic rates. A study conducted in Qatar found that supplementing NMN in animal models led to increased gene expression of two key hormones in appetite suppression and metabolism control, leptin and sirtuin, respectively. This study shows that oral NMN ingestion could suppress hunger to help you lose weight while also increasing your metabolism rate, both of which exaggerate the weight loss you may be experiencing.
In addition, the researchers found that NMN increases levels of NAD + which in fat cells has a metabolic-enhancing effect, further promoting weight loss.
Control of diabetes
Diabetes is one of the complications of obesity, and the use of NMN supplements to manage and treat obesity can prevent the development of diabetes. But this isn't NMN's only effect on blood sugar levels. The decrease in NAD + levels has been found to be related to the reduced functioning of beta cells in the pancreas, the main source of insulin in the body. Researchers believe this is the main pathophysiology underlying the development of type 2 diabetes mellitus in older individuals.
A study in animal models showed that diabetic and elderly mice, when given NMN supplements, had better beta cell function as they replenished NAD + stores in the body. Another study focusing on finding a treatment goal for type 2 diabetes mellitus associated with age and obesity found that NMN supplements had the potential to affect the liver and increase fat oxidation.They could also reduce the accumulation of fat in the body while also improving the glucose tolerance in the body.
NMN supplements have several pathways through which they help improve glucose tolerance and insulin resistance, thereby helping manage type 2 diabetes mellitus in older individuals. Similar pathways are used to effectively relieve the symptoms of other metabolic disorders that develop during the aging process.
Increase in the function of the immune system
Given that NMN supplementation has only recently become a viable option that has been studied, at least in animal models, it is no wonder that the role of NMN has been investigated regarding COVID-19 infection. .
By studying the different roles of the multitasking coenzyme, NAD +, the researchers found that it also plays a vital role in the proper functioning of the immune system. The recent COVID-19 pandemic has prompted researchers to investigate the specific connection between NMN supplements, increased NAD +, and enhanced immune function to counter the effects of the virus.
One of these studies found that NAD + levels were depleted and, as a result, age increased, resulting in severe infections. It was also found that these patients were at higher risk of comorbidities and mortality due to COVID-19 infection. As a result of these findings, it can be hypothesized that NMN supplementation may be able to reduce the severity with which COVID-19 affects the immune system and the human body.
· Improved female fertility
Women are affected by the biological clock which limits their reproductive capabilities with age. Several studies conducted in female animal models have found that NMN supplementation may be able to reduce these limitations and even treat age-associated infertility in some cases.
A study in naturally aged female mice found that depletion of NAD + levels can lead to a decrease in egg quality along with a significant decrease in egg number, which consequently reduces reproductive capacity and fertility. It has been found that restoring NAD + levels in these animal models with NMN supplementation increases the quality of the oocyte and its number, thereby improving the ability to reproduce.
Another study was conducted to evaluate exactly what reduces egg quality with age. For this study, oocytes from elderly females were collected and studied in depth to understand their pathophysiology. The researchers found that the decrease in oocyte quality was the result of point mutations in the oocyte's mitochondrial DNA, which develops due to an imbalance in NAD + levels. This is why supplementing NMN to increase NAD + levels is believed to improve fertility and reproductive health, especially in older women.
As older women lose most of their reproductive abilities during menopause, NMN supplements, in addition to being able to improve reproductive health, may also be able to reverse menopause to some extent. This would allow women to be fertile longer and have higher egg quality even after passing the general age threshold.
Increased blood flow
According to research conducted by Dr. DAvid Sinclair, the biologist responsible for the reputation of NMN supplements, as we age, the endothelial cells that line our blood vessels decrease in number and quality.This then affects the nutrients that pass from the blood to the tissues through which the vessels pass, thereby affecting the overall quality of the blood vessel. These changes are believed to be the major factor behind the increased incidence of blood vessel disease among older individuals.
NMN supplementation or NR supplementation results in increased levels of NAD +, which according to this study causes endothelial cells to become active and potent to produce new blood vessels when old ones stop functioning properly.
· Advanced cognitive function
Neurodegenerative disorders are common disorders that affect the brain, reducing cognitive function and quality of life. Supplementing with NMN to increase NAD + levels is believed to be highly effective in improving cognitive function and improving brain cell survival.
In a study in which animal models with head injury and neurodegeneration were given a specific compound, P7C3-A20, it was found that this compound improved cognitive function and disrupted neurodegenerative processes.
P7C3-A20 is a compound that produces NMN which then produces NAD +. Giving mice with TBI this compound was not only found to have cognitive benefits, it was also found to increase the functional and structural integrity of the blood-brain barrier, as this compound is a part of the membrane.
· Improved muscle function and increased endurance
Athletes looking to improve their stamina should take NMN supplements as these supplements have recently been found to have the potential to improve their aerobic capacity.This benefit of NMN supplements is mainly due to the energy producing effect of NAD + in the muscle, but it is important to note that these athletes also experience a significant increase in the oxygen uptake levels of their muscles.
Should i take NMN powder?
NMN Powder has several advantages that have been studied in detail, in animal models and in the laboratory. Some of these benefits have been studied in humans and have produced positive results. If you are starting to see the signs of aging, be it in the form of reduced stamina, athletic ability, or aesthetic signs, you may benefit from taking NMN supplements. Their use is especially recommended for those looking to reverse the symptoms of aging.
Potential NMN risks
NMN is a compound naturally present in the human body, which after extensive research and analysis was found to have no associated risks or complications. NMN, when properly manufactured by the NMN supplier and stored properly in the NMN powder factory and in your home, is completely safe for human consumption. Storing NMN powder is important because if it is stored in a warm place, it will turn into niacinamide and slowly start poisoning your body when you consume it.
You don't have to worry as the pure NMN powder from NMN company is always stored properly, in a cold and dry place. In addition, NMN powder manufacturers also print the exact instructions for use and storage on the packaging of the supplements so that you know how to use them best, without causing serious complications.
It is also worth noting that regular use of NMN supplements can result in the supplements' reduced ability to produce the desired effects.For this reason, it is recommended that you take a break from supplements when you begin to notice a decrease in NMN benefits, such as reduced sleep quality and an increased incidence of infections.
As for proper care during the manufacturing and storage process, whether at home or in the factory, there are no risks and side effects associated with using NMN.
Where to buy the best NMN powder?
You can purchase NMN powder and other forms of NMN supplements from online pharmacies, health stores, and local counterparts. You can also buy bulk NMN powder bags that contain massive amounts of NMN powder, although it is industrial quality and most commonly purchased from large companies looking to make NMN pills and capsules.
You can also buy NMN powder from Amazon or Amazon Prime, but you should be careful to buy the real product from verified suppliers as many random sellers could trick you into paying a huge sum for a duplicate or a fake, which has no effect on your health. or has a negative effect on your health.
Before you start buying NMN powder, you should check a few things to make sure you are purchasing the best product for you.
The best NMN supplement is the one manufactured with all safety guidelines and protocols in place. NMN suppliers should ensure that maximum attention is given to preventing NMN dust contamination with toxins or contaminants that can cause more harm than good to the human body.
Furthermore, NMN powder should be, as stated above, should be stored in proper conditions which should also be maintained while transporting the supplements.
Frequently Asked Questions About NMN Powder
· Can NMN Powder Reverse Aging?
NMN powder is advertised as an anti-aging supplement and rightfully so, as it increases levels of NAD + which plays a crucial role in reducing energy levels as we age. Not only that, NMN powder can reverse the effects of aging on different organ systems in your body and bring you back to your young and energetic days.
· Is NMN powder safe?
NMN powder has been thoroughly researched to evaluate the different functions and benefits its use can have on the human body. During these studies, potential side effects were also analyzed for the results alone to show that NMN use has no side effects associated with it. Any complication that can occur with the use of NMN powder is the result of a human or material error made during transportation or storage. None of this has to do with the actual ingredient in the anti-aging supplement.
· How much does NMN powder cost?
NMN powder is a readily available and relatively expensive supplement, but it's worth it, given its huge list of scientifically proven benefits. The high price of NMN powder is not due to the long list of benefits, but rather to the extremely extensive manufacturing process which in itself is quite expensive for most NMN manufacturers. Given the expensive nature of the supplement, you should always make sure you are purchasing the real product from certified suppliers, especially if you are buying NMN online.
NMN supplements are becoming more popular by the day, thanks to the work of biologist David Sinclair who has also devoted a significant portion of his academic career to researching and studying the effects of this vitamin B3-derived nucleotide.
NMN is a precursor of NAD +, a coenzyme necessary for the proper functioning of various metabolic, immune and hormonal pathways.The main function of NAD + is the role it plays in the energy production process. Since NAD + is essential for energy production, the physiological decrease in its levels with advancing age causes a marked reduction in energy levels. NMN supplementation can help increase energy by increasing NAD + levels in the body.
NMN also has many other benefits such as improved metabolic function, improved cardiac, cognitive, circulatory and immune system functions. These features are backed up by scientific evidence and data, requiring widespread use of NMN supplementation in older people to help them travel through time to the days of their youth.
In addition to the many benefits of NMN, its popularity can also be attributed to the fact that it does not have any significant risks or complications associated with its use. If you feel your age is catching up with you and you want a drink from the fountain of youth, NMN supplements may be the best choice for you.
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