Nicotinamide Chloride Riboside

Description

Basic features

product name Nicotinamide Chloride Riboside CAS number 23111-00-4 Molecular formula C11H15ClN2O5 Weight Formula 290.7 Synonyms 23111-00-4

Nicotinamide Chloride Riboside

Nicotinamide riboside (chloride)

3-Carbamoyl-1 – ((2r, 3r, 4s, 5r) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride

Nicotinamide ribose chloride

Form White powder Storage and management 0-4 C for the short term (days to weeks) or -20 C for the long term (months).

Nicotinamide riboside chloride Description

Nicotinamide riboside chloride (NIAGEN) is the chloride salt form of nicotinamide riboside (NR). NR is a new pyridine-nucleoside form of vitamin B3 that acts as a precursor of nicotinamide adenine dinucleotide (NAD) or NAD +. NIAGEN is generally recognized as safe (GRAS) in the United States for use in food. Nicotinamide riboside chloride is a crystalline form of nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD [+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against metabolic abnormalities induced by a high-fat diet. Nicotinamide Riboside Chloride Powder is used in food supplements.

Mechanism of action of nicotinamide riboside chloride

Nicotinamide riboside chloride (NIAGEN) is the chloride salt form of nicotinamide riboside (NR). NR is a pyridine-nucleoside form of vitamin B3 that functions as a precursor of nicotinamide adenine dinucleotide or NAD +.NR blocks ex vivo degeneration of surgically severed dorsal root ganglion neurons and protects against noise-induced hearing loss in live mice. Nicotinamide Riboside Powder prevents senescence of muscle, neural and melanocyte stem cells. An increase in muscle regeneration in mice was observed after treatment with nicotinamide riboside, leading to speculation that it could improve the regeneration of organs such as the liver, kidneys and heart. Nicotinamide riboside also reduces blood glucose and fatty liver in prediabetic and type 2 diabetic models, preventing the development of diabetic peripheral neuropathy. Note: Nicotinamide riboside chloride is an α / β mixture.

Application of Nicotinamide Riboside Chloride

Nicotinamide Riboside Chloride Powder is registered under CAS number 23111-00-4 and EC number 807-820-5. Its IUPAC name is 1 – [(2R, 3R, 4S, 5R) ‐3,4 – dihydroxy – 5‐ (hydroxymethyl) oxolan – 2 – the] pyridine – 1 – – 3 – carboxamide, chloride. The molecular formula of Nicotinamide Riboside Chloride is C11H15N2O5Cl and its molecular weight is 290.7 g / mol. Nicotinamide riboside chloride (NIAGEN) is the chloride salt form of nicotinamide riboside (NR) .NR is a new pyridine-nucleoside form of vitamin B3 that functions as a precursor of nicotinamide adenine dinucleotide (NAD) or NAD +. The body needs NAD + to function normally. Low levels of NAD + can cause medical problems. Taking nicotinamide riboside can help increase these low NAD + levels.

Advantages of Nicotinamide Chloride Riboside

Nicotinamide riboside chloride, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3.Nicotinamide Riboside Chloride Powder is a source of Vitamin B3 (Niacin), and the use of Nicotinamide Riboside Chloride Powder can improve oxidative metabolism, protecting against metabolic abnormalities induced by a high fat diet. Nicotinamide riboside chloride reduces cognitive impairment in a transgenic mouse model of Alzheimer's disease.

Reference

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